Purine nucleotides
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | 99.9% | 569.44 | C22H29N5O9P2 | 25 MG
Motesanib diphosphate is a small-molecule, ATP-competitive inhibitor of vascular endothelial growth factor receptors VEGFR1, VEGFR2, and VEGFR3 that also inhibits Kit. The diphosphate salt is supplied for research and analytical applications.
- Potent VEGFR1/2/3 inhibition (IC50 ~2 nM, 3 nM, 6 nM).
- Also inhibits Kit, with ~10-fold selectivity for VEGFR versus PDGFR and Ret.
- High purity (≈99.86%) with molecular weight 569.44 and formula C22H29N5O9P2.
- Supplied as a 25 mg research/analytical sample.
- Intended for non-clinical, research use only.
![Research Products International Corp Coenzyme A Trilithium Salt [Acetyl Coenzyme A, Trilithium Salt], 100 Milligrams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-C95275-0.1.JPG-250.jpg)
Research Products International Corp Coenzyme A Trilithium Salt [Acetyl Coenzyme A, Trilithium Salt], 100 Milligrams
Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes.
Sigma Aldrich Fine Chemicals Biosciences D Ribulose 15 Diphosphate
Exists as a 557AkDa hexadecamer composed of eight heavy chains each with a molecular weight of approximately 56AkDa and eight light chains of molecular weight 14AkDa. Each molecule contains one magnesium ion. pH optimum ~7.9. KM for CO2 ~0.45 mM. Ribulose diphosphate becomes inhibitory at concentrations exceeding 0.7 mM. Orthophosphate and ammonium sulfate are competitive inhibitors. 3-Phosphoglycerate is a noncompetitive inhibitor.
Abcam Iodotubercidin, adenosine kinase inhibitor, 1MG
MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC₅₀ = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Motesanib diphosphate | 857876-30-3 | MFCD12407403 | 99.9% | 569.44 g/mol | C22H29N5O9P2 | 100 MG
Motesanib diphosphate is the diphosphate salt of a small-molecule ATP-competitive inhibitor of vascular endothelial growth factor receptors (VEGFR1/2/3). It is supplied as a research-grade analytical standard for biochemical assays, pathway studies, and method development. The compound should be stored sealed and protected from moisture; in solvent, stability is -80°C for up to six months and -20°C for up to one month.
- High purity (~99.9%).
- Potent VEGFR1/2/3 inhibition with IC50s 2-6 nM.
- Molecular formula C22H29N5O9P2, molecular weight 569.44 g/mol.
- Suitable for biochemical assays and analytical method development.
- Storage: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.2% | 512.15 | 50 MG
Inosine 5'-diphosphate sodium is a purine ribonucleoside 5'-diphosphate that features inosine as its nucleobase. This compound is known for its role in intracellular energy metabolism and signal transduction processes.
- A purine ribonucleoside 5'-diphosphate
- Inosine is the nucleobase
- Participates in intracellular energy metabolism
- Involved in signal transduction processes
- Relevant to respiratory disease research
- Applicable to metabolic or endocrine disease studies
- Used in pulmonary disease research
- Investigated in lung fibrosis studies
- Can be classified as an oligonucleotide
- Functions as a nucleotide analog
- Related to inosine compounds
- Identified as a nucleoside
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.17% | 512.15 | 500 MG
Inosine 5'-diphosphate sodium is a purine ribonucleoside 5'-diphosphate with inosine as the nucleobase. It participates in intracellular energy metabolism and signal transduction processes.
- Purine ribonucleoside 5'-diphosphate
- Contains inosine as the nucleobase
- Participates in intracellular energy metabolism
- Involved in signal transduction processes
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | MFCD16627994 | 100.0% | 681.49 g·mol^-1 | C26H32F3N3O11P2 | 10 MG
Sonidegib diphosphate is the diphosphate salt of sonidegib, a potent and selective Smoothened (Smo) antagonist used in research to inhibit Hedgehog pathway signaling. It shows low-nanomolar binding potency in Smo assays and is supplied for laboratory use with supporting datasheet and safety documents.
- Potent Smo antagonist with low-nanomolar binding (mouse 1.3 nM; human 2.5 nM).
- Diphosphate salt form suitable for aqueous assay conditions.
- Supplied as a 10 mg vial for research use.
- Molecular weight 681.49 g·mol^-1; formula C26H32F3N3O11P2.
- Storage: sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
TARGETMOL CHEMICALS INC GUANOSINE 5-DIPHOSPHATE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. purity: 98%
Sigma Aldrich Fine Chemicals Biosciences Adenosine 35-diphosphate d10MG
3AE-phosphoadenosine 5AE-phosphate (PAP) a 3AE-phosphorylated nucleotide is found in almost all organisms and is obtained as a by-product of sulfur and lipid metabolism.
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 10mM (in 1mL DMSO)
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Medchemexpress LLC 7-Methylguanosine 5'-diphosphate sodium | 104809-16-7 | 97.1% | C11H16N5NaO11P2 | 1 MG
7-Methylguanosine 5'-diphosphate sodium is a cap analog used in the synthesis of mRNA cap analogues.
- Inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA.
- Is a substrate for T. brucei mRNA decapping enzyme (TbDcp2) which cleaves it from capped RNA to generate pRNA.
Research Products International Corp Coenzyme A Trilithium Salt 1 G
Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes.